I was been asked to fix the sccm email notification since no one getting any email from sccm for Defender Alerts, etc.
After researching i found that if your organization using Office 365 and your exchange server is on the cloud, you should always use this settings :
DomainName-com.mail.protection.outlook.com
1- Navigate to : Administration > Site Configuration > Sites.
click to Configure Site Components > Email Notification. and Click “Enable email notification for alerts”.
2- use the following settings:
FQDN: DomainName-com.mail.protection.outlook.com
Port: 25
Acct: Domain\username or None
Sender email: No-REply@Domain.com or any email
3- click on “Test SMTP Server” add your email and click send test email.
4- yuou should receive email shortly.
For more details, please refer to Microsoft documentation: